Understanding the Use of Stem Cells and Microchanneling in Skincare

Stem Cells and Growth Factors in Skin Regeneration

Stem cells play a vital role in tissue regeneration. There are three primary types:

Embryonic stem cells (ESCs): These can develop into any cell type and are responsible for forming the human body in the womb.

Adult stem cells: These generate specific cell types within their respective tissues or organs.

Induced pluripotent stem cells (iPSCs): Created in a lab, these are reprogrammed adult cells that mimic embryonic stem cells.

All stem cells work together in an organ-specific manner, forming a complex system of tissue repair and regeneration. Growth factors are naturally occurring proteins that regulate cell growth, proliferation and differentiation. They maintain skin structure and replace aging cells. These proteins are secreted by keratinocytes, fibroblasts and melanocytes (key cell types in the epidermis and dermis). 

Certain beta-glucans also act as growth factors, enhancing Langerhans cells’ function. This process activates macrophages, strengthening the skin’s defense against free radicals, bacteria, viruses and parasites.

Do Plant Stem Cells Work in Skincare?

A common question in the skincare industry is whether plant stem cells in serums or creams interact with human stem cells. The answer is no.

Plant stem cells are extracted by wounding plant tissue, triggering a response that forms a mass of undifferentiated cells called a callus. This callus is often used in plant-based stem cell skincare formulations. However, plant stem cells do not share a genetic blueprint with human cells and cannot directly influence human stem cell activity.

Even if plant cells had regenerative properties, they are too large to penetrate the skin barrier. While plant extracts may provide beneficial micronutrients, they should be considered “skin food” rather than true stem cell therapy. Their effectiveness depends on extraction methods, bioavailability and delivery systems.

Sources of Growth Factors in Regenerative Aesthetics

Not all growth factors are equal. Here’s how different sources compare:

• Autologous (Platelet-Rich Plasma, PRP): Derived from a patient’s own blood, PRP contains growth factors but can induce inflammation, potentially counteracting its benefits.
• Allogenic (Donor Stem Cells): Sourced from other individuals, these growth factors vary in potency, leading to inconsistent results.
• Bio-Engineered Growth Factors: Created in controlled lab environments, these serums provide a purified, stable and targeted blend of regenerative signals without the variability of PRP or donor cells.

Harnessing Human Stem Cells for Skin Regeneration

For human stem cells to be effective in skincare, three key steps are necessary:

1. Accessing stem cells while minimizing inflammation (some activation is beneficial).

2. Encouraging stem cells to transition into new roles, such as keratinocyte or fibroblast production.

3. Supporting differentiation more than at least 47 days to maximize epidermal renewal.

What About Exosomes?

Exosomes, tiny extracellular vesicles carrying proteins, RNA and growth factors, have gained attention in regenerative medicine. However, concerns remain:

1. Lack of FDA Approval: Exosomes are not yet FDA-approved for skin rejuvenation.

2. Safety Considerations: They can cross the blood-brain barrier, raising long-term safety questions.

3. Inconsistent Quality: Exosome formulations vary widely, affecting predictability and efficacy.

The Role of Microchanneling in Skin Regeneration

Cytokines and growth factors act as cellular messengers, signaling skin cells to repair, reduce inflammation and regenerate. While the body naturally produces these bio-signals, aging and environmental damage slow the process.

Microchanneling creates controlled micro-injuries, reactivating the skin’s healing mechanisms while allowing stem cell-derived growth factor serums to penetrate deeper, enhancing results.

Microchanneling vs. Traditional Microneedling

Microchanneling provides scientifically backed collagen stimulation using a precise stamping technique rather than the dragging motion of microneedling, which can cause microscopic tears. Microchanneling technology ensures controlled depth and consistent results without requiring deep penetration, leading to less irritation and faster healing over traditional microneedling.

When combined with clinically validated growth factor serums, microchanneling can enhance skin rejuvenation, effectively treating fine lines, scars, acne scars, hyperpigmentation and overall skin health.

Choosing the Right Stem Cell and Growth Factor Serums
It is essential to select advanced serums that are clinically backed, bio-engineered and formulated for stability and cellular repair. Prioritizing scientifically validated ingredients over trends lacking regulatory approval or long-term research ensures optimal skin health and regeneration. FBN

By Ashley Dial

To schedule an appointment with Ashley Dial, visit www.etherealestheticsbyashley.glossgenius.com or call 928-864-8438. Ethereal Esthetics is located at 519 N. Leroux, Downtown Flagstaff, inside Studio Rox. Mention this article to receive 15% off your first service!

Ashley Dial is owner, operator and licensed esthetician of Ethereal Esthetics By Ashley. For more information and a free consultation, please visit her website or give her a call.